11/7/2023 0 Comments Lateral tests![]() The electronic-LFA uses a biological trigger employing the well-known enzyme glucose oxidase. The approach of the MIT team generates base signals in which the resistance can change by 700,000 percent, and with these strong signals, can detect trace quantities of a target biomarker. It can be readily measured with great accuracy, and prior research has shown that the group’s electronic LFAs have both intrinsic quantitative capabilities and ultra-high sensitivity. 17 in the Journal of the American Chemical Society, members of the lab of Professor Tim Swager, led by postdoc Jie Li and graduate student Weize Yuan, reveal the design for a new generation of LFA that uses conductivity (or resistivity) changes in an electronic polymer to create the response.Įlectrical resistance (or conductance) is universal in electronic devices. Since Covid has catapulted LFAs into the daily lives of many, the impact of these tests will be even greater if they can be made intrinsically quantitative for the monitoring of key biomarkers associated with disease progression, medical treatments, and basic health monitoring. Various attempts to make a quantitative LFA have yielded complications due to the optical basis of a quantitative test - scattered stray light and faint images. ![]() In their current iteration, these tests are largely qualitative and binary in their outputs. Lateral flow assays (LFA) tests have become ubiquitous within the general public they are the format for standard home pregnancy and Covid-19 tests, indicating a positive result with a colored line, and a negative result with no colored line.
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